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Journal Articles Open Forum Infectious Diseases Year : 2020

Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

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Abstract

Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV-bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV-bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30-6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed.

Dates and versions

hal-03149230 , version 1 (22-02-2021)

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Raphael Godefroy, Audrey Giraud-Gatineau, Marie-Therese Jimeno, Sophie Edouard, Line Meddeb, et al.. Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults. Open Forum Infectious Diseases, 2020, 7 (12), ⟨10.1093/ofid/ofaa546⟩. ⟨hal-03149230⟩
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