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Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department

Abstract : Aim: In an Emergency Department (ED), the etiological identification of infected subjects is essential. 13 infection-related biomarkers were assessed using a new flow cytometry procedure. Materials & methods: If subjects presented with febrile symptoms at the ED, 13 biomarkers' levels, including CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), were tested and compared with clinical records. Results: Among 50 subjects, 78% had bacterial infections and 8% had viral infections. nCD64 showed 82% sensitivity and 91% specificity for identifying subjects with bacterial infections. mCD169, HLA-ABC ratio and HLA-DR on monocytes had high values in subjects with viral infections. Conclusion: Biomarkers showed promising performances to improve the ED's infectious stratification.
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https://hal-amu.archives-ouvertes.fr/hal-03163533
Contributor : Annick Prémilleux <>
Submitted on : Tuesday, March 9, 2021 - 4:22:06 PM
Last modification on : Thursday, March 11, 2021 - 4:59:48 PM

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Penelope Bourgoin, Guillaume Lediagon, Isabelle Arnoux, Denis Bernot, Pierre-Emmanuel Morange, et al.. Flow cytometry evaluation of infection-related biomarkers in febrile subjects in the emergency department. Future Microbiology, Future Medicine, 2020, 15 (3), pp.189-201. ⟨10.2217/fmb-2019-0256⟩. ⟨hal-03163533⟩

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